Central Sensitization: A Hidden Cause of Chronic Pain and Neuropathy

May 10, 2025

Central Sensitization-understanding what it is, the symptoms and available treatment options such as Calmare Scrambler Therapy
Central Sensitization-understanding what it is, the symptoms and available treatment options such as Calmare Scrambler Therapy

Chronic pain can be complex and frustrating, especially when traditional treatments don’t provide relief. One often-overlooked factor behind persistent pain is Central Sensitization - a condition where your nervous system becomes hypersensitive, amplifying pain signals and making even normal sensations feel uncomfortable or painful. Central Sensitization occurs when the central nervous system (the brain and spinal cord) becomes more reactive to pain signals. Instead of just responding to actual injuries, your nervous system starts to overreact, turning up the pain ‘volume’ even when there’s no ongoing tissue damage. Central Sensitization is a key concept in chronic pain and neuropathy, including small fiber neuropathy.

How Does It Develop?

Repeated or ongoing nerve injury, such as in small fiber neuropathy, can cause persistent pain signals that keep firing, even after the original injury heals. Over time, neurons in the spinal cord and brain become hyper-excitable. The threshold for pain activation lowers, so light touch or mild stimuli can cause intense pain (a phenomenon called allodynia). Pain can spread beyond the original injury site, and discomfort may persist long after the initial problem.

Why Is This Important?

Understanding Central Sensitization is essential because it shifts how we approach chronic pain. Rather than just focusing on the original injury or nerve damage, recognizing this condition highlights the role of the nervous system’s heightened sensitivity in perpetuating pain. This means:

  • Pain may persist or even worsen long after the initial injury has healed, making it clear that the problem isn’t solely tissue damage.

  • Pain can spread beyond the original site, leading to widespread discomfort that’s difficult to explain with traditional injury-based models.

  • Without addressing Central Sensitization, treatments that target only the tissues or nerves may fall short, leaving patients feeling frustrated and hopeless.

By identifying Central Sensitization as a key factor, we can develop more effective, multi-faceted treatment plans that involve both physical and neurological approaches. This comprehensive understanding empowers patients to take control of their pain and seek therapies that address the root causes, improving outcomes and quality of life.

Recognizing the Symptoms

Individuals with Central Sensitization may experience:

  1. Widespread, diffuse pain

  2. Increased sensitivity to touch, temperature, or pressure

  3. Pain from normally non-painful stimuli (allodynia)

  4. Exaggerated response to painful stimuli (hyperalgesia)

  5. Fatigue, sleep disturbances, and mood changes

Conditions Linked to Central Sensitization

Central Sensitization doesn’t just happen in isolation. It is often a key factor in a variety of chronic conditions that involve persistent or widespread pain. Recognizing these links can help in understanding the underlying causes of discomfort and tailoring effective treatment option. Central Sensitization is often associated with:

  • Small fiber neuropathy

  • Fibromyalgia

  • Complex Regional Pain Syndrome (CRPS)

  • Chronic headaches (migraines)

  • Irritable bowel syndrome (IBS)

  • Temporomandibular Joint Disorders (TMJ)

How Can Calmare® Scrambler Therapy LA Help?

Addressing Central Sensitization requires a comprehensive approach. At Calmare® Scrambler Therapy LA, we offer specialized treatments focused on calming the nervous system, reducing pain, and improving quality of life. Our treatment options include:

  1. Calmare® Scrambler Therapy (electrical signals that “scramble” the pain signal)

  2. Spinal adjustments and manual therapy to improve nervous system function

  3. Desensitization techniques to gradually reduce nerve hypersensitivity

  4. Neurofeedback and therapeutic exercises tailored to your needs

  5. Lifestyle counseling including stress reduction techniques and education about pain management

  6. Collaborative care with other healthcare providers to ensure a holistic approach

Take Control of Your Pain Today

If you’re struggling with chronic pain or neuropathy, understanding Central Sensitization is the first step toward relief. Dr. Orlando is here to help you explore personalized treatment plans that address the root causes of your pain and restore your well-being. Contact us today to learn more about how Dr. Orlando can help you manage and reduce symptoms of Central Sensitization and regain control of your life!

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